Abstract #2533

Sensitivity to pathological normal appearing white matter damage in multiples sclerosis – a comparison of DTI and DKI

Tim Sprenger^1,2, Michael Czisch³, Brice Fernandez⁴, Ines Eidner³, Jonathan I. Sperl⁵, Axel Haase¹, Frank Weber³, Marion I. Menzel⁵, and Philipp G. Sämann³

¹Technische Universität München, Munich, Germany, ²GE Global Research, Munich, Germany, ³Max Planck Institute of Psychiatry, Munich, Germany, ⁴GE Heathcare, Paris, France, ⁵GE Global Research, Munich

A systematic comparison of diffusion tensor imaging (DTI) and diffusional kurtosis imaging (DKI) regarding the sensitivity to non-pathological white matter in multiple sclerosis is presented. We found first indications for a higher sensitivity of DKI compared with DTI in the normal appearing white matter compartment.

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