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Abstract #2538

Investigation on Optic Neuritis with DTI and Understanding Its Underlying Pathology using Monte Carlo Simulation.

You Jung Lee1, Seoung-Eun Kim1, John Rose2, Eun-Ju Kim1, Karen Salzman3, Bradley Katz2, and Eun-Kee Jeong1,3

1Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 2Department of Neurology, University of Utah, 3Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

To understand the underlying physical and pathological meaning of optic-nerve in optic-neuritis(ON), diffusion-tensor imaging (DTI) and the corresponding Monte-Carlo Simulation (MCS) were conducted. DTI studies of four healthy subjects and seven ON patients with MS were performed and analyzed by home-built software. The measured DTI indices allowed us to monitor pathological changes such as inflammation in ON or demyelination. To investigate the clinical meanings of changes in diffusion parameters, MCS of water diffusion in optic nerve was performed.

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