To understand the underlying physical and pathological meaning of optic-nerve in optic-neuritis(ON), diffusion-tensor imaging (DTI) and the corresponding Monte-Carlo Simulation (MCS) were conducted. DTI studies of four healthy subjects and seven ON patients with MS were performed and analyzed by home-built software. The measured DTI indices allowed us to monitor pathological changes such as inflammation in ON or demyelination. To investigate the clinical meanings of changes in diffusion parameters, MCS of water diffusion in optic nerve was performed.
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