Abstract #2542

Ultra High Field Regional Quantitative Susceptibility Mapping in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study

Jon Orlando Cleary¹, Amanda Ng¹, Camille Shanahan^1,2, Yasmin Blunck¹, Myrte Strik^1,2, Brad A Moffat¹, Trevor J Kilpatrick², Roger J Ordidge¹, and Scott C. Kolbe^1,2

¹Melbourne Brain Centre Imaging Unit, Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Australia, ²MS Research Group, Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Australia

Multiple sclerosis (MS) is typically characterised by hyperintense T2 white matter lesions. However, the quantity and location of these may not correlate to a patient’s functional state or impending disease progression. Quantitative susceptibility mapping (QSM) is an emerging biomarker associated with tissue iron concentration and regions of demyelination in white matter. This pilot study examined both clinical and MRI parameter relationships to the QSM value over a number of brain regions in patients with mild (EDSS =or<2) relapsing and remitting MS.

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