Diffusion tensor imaging (DTI) is considered as a biomarker to quantitatively evaluate the pathology in the cervical spinal cord (CSC) in MS patients. However, DTI parameters, including axial and radial diffusivities, and fractional anisotropy (FA), provides signal behavior of the water diffusion at a specific diffusion weighting. Using a ultra-high B DWI on a CSC specimen and Monte-Carlo Simulation indicate that we can learn much more insights about the CSC pathology by analyzing the signal-b curve at b > 4000 s/mm2. In this presentation, we will show unique signal behaviors of UHB-rDWI in acute and chronic legions in MS CSC.
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