Abstract #2580

Reproducibility and Age dependence of GluCEST contrast in healthy adults

Ravi Prakash Reddy Nanga¹, David Roalf², Kevin D'Aquilla¹, Catherine DeBrosse¹, Puneet Bagga¹, Neill Wilson¹, Dushyant Kumar¹, Ari Borthakur¹, Mark Elliott¹, Damodar Reddy¹, Hari Hariharan¹, Neill Cynthia Epperson^2,3, and Ravinder Reddy¹

¹CMROI, Radiology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, ²Psychiatry, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, ³Obstetrics and Gynecology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA

In this study we employed the single-slice 2D glutamateCEST (GluCEST) MRI to measure the reproducibility as well as changes in GluCEST with age in healthy human brains. GluCEST MRI appears to be a promising technique that can characterize neuronal changes in normal aging.

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