Abstract #2595

In Vivo 19F MRI for Non-invasively Investigating the Effects of Perfluorocarbon Nanoemulsion on High Intensity Focused Ultrasound Tumor Ablation

Soo Hyun Shin¹, Eun-Joo Park², Changki Min¹, Sun Il Choi¹, Soyeon Jeon¹, Yun-Hee Kim¹, and Daehong Kim¹

¹Molecular Imaging & Therapy Branch, National Cancer Center, Goyang, Korea, Republic of, ²Dept. of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of

Perfluorocarbon nanoemulsion (PFCNE) is currently studied as a precursor of microbubbles to accompany high intensity focused ultrasound (HIFU) for tumor ablation. We propose ¹⁹F MRI as a valuable tool for non-invasively assessing the effects of PFCNE concentration on therapeutic efficiency of HIFU. ¹⁹F MRI was used to determine the amount of PFCNE accumulated in a tumor before HIFU treatment. Tumor ablation was monitored by intra-voxel incoherent motion (IVIM) mapping, which was compared with PFCNE quantification from ¹⁹F MRI for identifying the PFCNE concentration that gives optimal therapeutic efficiency.

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