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Abstract #2604

Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme: A 7.0 T (298 MHz) study

Eva Oberacker1, Andre Kuehne2, Helmar Waiczies2, Jacek Nadobny3, Sebastian Zschaeck3, Pirus Ghadjar3, Peter Wust3, Thoralf Niendorf1,2,4, and Lukas Winter1

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2MRI.TOOLS, Berlin, Germany, 3Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, Germany, 4Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Glioblastoma multiforme is the most frequent and most aggressive malignant braintumor with de facto no long term curation by the use of current multimodal therapeutic approaches. RF heating at ultrahigh fields (B0=7.0T, f=298MHz) has the potential of delivering sufficiently large thermal dosage for hyperthermia of relatively large tumor areas. This work focuses on EMF simulations and provides realistic applicator designs tailored for simultaneous RF heating and MR imaging. Our preliminary results suggest that RF power can be focused to both a small tumor area and a big clinical target volume based on segmented patient data.

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