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Abstract #2613

MRI of Intra-Tumoral Iron-Oxide Labeled Clostridium novyi-NT Injections During Bacteriolytic Therapy in Solid Tumors

Jingran Ji1, Woo Ram Park1, Yihe Yang1, Soojeong Cho1, Xiaoke Huang1, Kathleen Harris1, Weiguo Li1, Dong-Hyun Kim1, Zhuoli Zhang1, and Andrew Christian Larson1

1Northwestern University, Chicago, IL, United States

Bacteriolytic therapy with Clostridium novyi-NT has shown promise as a form of cancer treatment, but concerns remain regarding route of delivery and toxicity. Our study aimed to develop a method to visualize delivery with MRI during bacteriolytic therapy. We did so by incubating bacteria with iron oxide particles. In vitro viability studies and labeling efficiency studies were then performed, followed by phantom studies. Bacteria were then directly injected into rat liver tumors as well as mouse flank tumors and imaged. We demonstrate that the labeled bacteria can be directly visualized on MRI and is a reliable indicator of successful delivery.

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