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Abstract #2618

Multiparametric Comparison of Quantitative Susceptibility Mapping, R2*, and 89Zr-PET for Quantification of Targeted Magnetic Drug Therapy Biodistribution

Caroline D. Jordan1, Sravani Kondapavulur1, Andre M. Cote1, Misung Han1, Kiel D. Neumann1, Peder E. Z. Larson1, Henry F. VanBrocklin1, Alastair J. Martin1, and Steven W. Hetts1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

Targeted magnetic drug delivery could reduce toxicity of transarterial chemoembolization when used in combination with a magnetic filtration device, and accurate quantification is necessary. We utilized 89Zr-iron oxide nanoparticles (IONP) to evaluate quantitative susceptibility mapping (QSM), R2*, and 89Zr-PET uptake. Phantom evaluations demonstrated linear correlation between QSM, R2*, and 89Zr-PET/MR. Substantial increase in QSM and R2* was observed in a single hepatic lobe in a preliminary in vivo experiment after injection using MR only. These cross-validated techniques demonstrate a linear relationship between IONP concentration and QSM, R2*, and 89Zr-PET in vitro and show promise in assessing magnetic nanoparticle tracking.

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