Abstract #2618

Multiparametric Comparison of Quantitative Susceptibility Mapping, R2*, and 89Zr-PET for Quantification of Targeted Magnetic Drug Therapy Biodistribution

Caroline D. Jordan¹, Sravani Kondapavulur¹, Andre M. Cote¹, Misung Han¹, Kiel D. Neumann¹, Peder E. Z. Larson¹, Henry F. VanBrocklin¹, Alastair J. Martin¹, and Steven W. Hetts¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

Targeted magnetic drug delivery could reduce toxicity of transarterial chemoembolization when used in combination with a magnetic filtration device, and accurate quantification is necessary. We utilized ⁸⁹Zr-iron oxide nanoparticles (IONP) to evaluate quantitative susceptibility mapping (QSM), R₂*, and ⁸⁹Zr-PET uptake. Phantom evaluations demonstrated linear correlation between QSM, R₂*, and ⁸⁹Zr-PET/MR. Substantial increase in QSM and R₂* was observed in a single hepatic lobe in a preliminary in vivo experiment after injection using MR only. These cross-validated techniques demonstrate a linear relationship between IONP concentration and QSM, R₂*, and ⁸⁹Zr-PET in vitro and show promise in assessing magnetic nanoparticle tracking.

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