Abstract #2669

Multiple-Mouse Magnetic Resonance Imaging with CryoProbes

Aidin Arbabi¹, Dulcie A Vousden^1,2, Leigh Spencer Noakes¹, Jun Dazai¹, Shoshana Spring¹, John G Sled^1,2, Jason P Lerch^1,2, Mark Henkelman^1,2, and Brian J Nieman^1,2,3

¹Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Ontario Institute for Cancer Research, Toronto, ON, Canada

Multiple-mouse MRI was implemented on a 7-Tesla magnet with four Cryogen (liquid helium)-cooled radio frequency probes. The high signal-to-noise ratio offered by the probes enabled spatial resolutions of 60 μm isotropic in <2 hours, a significant improvement for in vivo anatomical imaging of the mouse brain. Several 3D pulse sequences including FLASH/MP2RAGE/RARE were implemented for multiple-mouse acquisition. Manganese-enhanced T1-weighted images were obtained at two different resolutions of 60 μm and 75 μm. Results demonstrate the combined benefits of cryogen-cooled coils and multiple-mouse MRI.

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