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Abstract #2669

Multiple-Mouse Magnetic Resonance Imaging with CryoProbes

Aidin Arbabi1, Dulcie A Vousden1,2, Leigh Spencer Noakes1, Jun Dazai1, Shoshana Spring1, John G Sled1,2, Jason P Lerch1,2, Mark Henkelman1,2, and Brian J Nieman1,2,3

1Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Ontario Institute for Cancer Research, Toronto, ON, Canada

Multiple-mouse MRI was implemented on a 7-Tesla magnet with four Cryogen (liquid helium)-cooled radio frequency probes. The high signal-to-noise ratio offered by the probes enabled spatial resolutions of 60 μm isotropic in <2 hours, a significant improvement for in vivo anatomical imaging of the mouse brain. Several 3D pulse sequences including FLASH/MP2RAGE/RARE were implemented for multiple-mouse acquisition. Manganese-enhanced T1-weighted images were obtained at two different resolutions of 60 μm and 75 μm. Results demonstrate the combined benefits of cryogen-cooled coils and multiple-mouse MRI.

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