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Abstract #2693

A chronic in situ coil system adapted for intracerebral stimulation during MRI in rats

Dan Madularu1, Chathura Kumaragamage2, Axel Mathieu1, Praveen Kulkarni3, M. Natasha Rajah1, Alain Gratton1, and Jamie Near1

1Psychiatry, McGill University, Montreal, QC, Canada, 2Biomedical Engineering, McGill University, Montreal, QC, Canada, 3Psychology, Northeastern University, Boston, MA, United States

We describe the fabrication and performance of a chronic in situ coil system designed to allow focal brain stimulation in awake rats while acquiring highly resolved MRI data. We developed a subcutaneously implantable receive-only surface radiofrequency coil to be fitted immediately adjacent to the rat skull surface during the cannulation procedure. SNR performance of the coil was superior to three commercially-available coils, in some instances by a factor of three. Widespread BOLD was observed in response to bicuculline and morphine microinfusions. This approach enables mapping the functional response to highly targeted stimuli such as microinfusions or optogenetics.

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