Abstract #2693

A chronic in situ coil system adapted for intracerebral stimulation during MRI in rats

Dan Madularu¹, Chathura Kumaragamage², Axel Mathieu¹, Praveen Kulkarni³, M. Natasha Rajah¹, Alain Gratton¹, and Jamie Near¹

¹Psychiatry, McGill University, Montreal, QC, Canada, ²Biomedical Engineering, McGill University, Montreal, QC, Canada, ³Psychology, Northeastern University, Boston, MA, United States

We describe the fabrication and performance of a chronic in situ coil system designed to allow focal brain stimulation in awake rats while acquiring highly resolved MRI data. We developed a subcutaneously implantable receive-only surface radiofrequency coil to be fitted immediately adjacent to the rat skull surface during the cannulation procedure. SNR performance of the coil was superior to three commercially-available coils, in some instances by a factor of three. Widespread BOLD was observed in response to bicuculline and morphine microinfusions. This approach enables mapping the functional response to highly targeted stimuli such as microinfusions or optogenetics.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.