Abstract #2697

Enhancement of signal intensity using a wireless coil for FT-EPR oximetry study, implanted in an animal body

Ayano Enomoto¹, Gadisetti V.R. Chandramouli², Alan P Koretsky³, Chunqi Qian⁴, Murali K Cherukuri¹, and Nallathamby Devasahayam¹

¹Radiation Biology Branch, National Cancer Institute, Bethesda, MD, United States, ²GenEpria Consulting Inc., Columbia, MD, ³National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ⁴Department of Radiology, Michigan State university, East Lansing, MI, United States

Improvement in sensitivity is required to detect the weak signals with Fourier transform Electron Paramagnetic Resonance (FT-EPR). In the proposed method, the signal from a wireless coil filled with sample was enhanced by using pumping coil in the regular EPR system. In this study, we achieved approximately 6-fold of improvement in signal intensity compared with conventional FT-EPR system under the simulated condition of animal body. We will also show the results of oximetry using the LiPc in, in vivo applications to measure tissue oxygenation.

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