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Abstract #2697

Enhancement of signal intensity using a wireless coil for FT-EPR oximetry study, implanted in an animal body

Ayano Enomoto1, Gadisetti V.R. Chandramouli2, Alan P Koretsky3, Chunqi Qian4, Murali K Cherukuri1, and Nallathamby Devasahayam1

1Radiation Biology Branch, National Cancer Institute, Bethesda, MD, United States, 2GenEpria Consulting Inc., Columbia, MD, 3National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 4Department of Radiology, Michigan State university, East Lansing, MI, United States

Improvement in sensitivity is required to detect the weak signals with Fourier transform Electron Paramagnetic Resonance (FT-EPR). In the proposed method, the signal from a wireless coil filled with sample was enhanced by using pumping coil in the regular EPR system. In this study, we achieved approximately 6-fold of improvement in signal intensity compared with conventional FT-EPR system under the simulated condition of animal body. We will also show the results of oximetry using the LiPc in, in vivo applications to measure tissue oxygenation.

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