Abstract #2730

Gender-based optimization of cardiac follow up in thalassemia major patients

Antonella Meloni¹, Laura Pistoia², Silvia Maffei¹, Giuseppe Peritore³, Valentina Vinci⁴, Massimiliano Missere⁵, Vincenzo Positano², Massimo Allò⁶, Antonella Massa⁷, and Alessia Pepe¹

¹Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ³"ARNAS" Civico, Di Cristina Benfratelli, Palermo, Italy, ⁴Azienda Ospedaliera "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy, ⁵Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, ⁶Presidio Ospedaliero ASL 5, Crotone, Italy, ⁷Ospedale “Giovanni Paolo II”, Olbia, Italy

Females seem to tolerate iron toxicity better, possibly as an effect of reduced sensitivity to chronic oxidative stress. Based on our data about the significantly different risk in developing cardiac complications, in females older than 20 years the FU may be performed every 24 months, thus optimizing health care costs.

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