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Abstract #2749

Reperfusion Hemorrhage Following Prolonged Myocardial Ischemia Leads to Fatty Degeneration of Myocardial Infarctions via Iron-Mediated, Self-Perpetuating Loop of Foam Cell and Ceroid Accumulation

Ivan Cokic1, Avinash Kali1, Hsin-Jung Yang1, Richard LQ Tang1, Joseph Francis2, and Rohan Dharmakumar1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Louisiana State University

Fatty infiltration within chronic myocardial infarctions (MI) is a common finding. It is typically observed in the peri-infarct border zone of old scars and has been linked to adverse outcomes in the chronic post-MI setting. To date, the trigger for fat deposition within old MI is unknown. Recent reports showed that iron deposits from hemorrhagic MI drive the recruitment of new monocytes/macrophages into the infarcted territory throughout the chronic phase after MI. Since iron-laden macrophages (siderophages) are prone to transforming into foam cells, we hypothesized that fatty degeneration of hemorrhagic myocardial infarctions has its origin in iron-driven foam cell formation.

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