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Abstract #2759

3D High Frequency Cardiac Magnetic Resonance Elastography Quantitatively Differentiates Myocardial Stiffness in Patients with HFPEF and Healthy Volunteers

Shivaram Poigai Arunachalam1, Arvin Arani1, Ian Chang2, Yi Sui1, Phillip Rossman1, Kevin Glaser1, Joshua Trzasko1, Kiaran McGee1, Armando Manduca3, Barry Borlaug2, Richard Ehman1, and Philip Araoz1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Cardiovascular Diseases, Mayo Clinic, 3Biomedical Engineering and Physiology, Mayo Clinic

Increased myocardial stiffness in patients with heart failure with preserved ejection fraction (HFpEF) is known to affect diastolic filling. The purpose of this work was to determine if 3D high frequency cardiac MR elastography (MRE) can quantitatively differentiate increased myocardial stiffness in HFpEF patients compared to healthy volunteers. Two patients with clinical diagnosis for HFpEF and 47 healthy volunteers were studied. The myocardial stiffness of HFpEF patients (mean: 10.57 kPa) was found to be significantly stiffer (p < 0.05) than healthy controls (mean: 7.79 kPa). Recruitment of more HFpEF patients is underway for further validation of this finding.

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