Heart muscle has a complex cellular helical arrangement, where bundles of myocytes, known as sheetlets interleave with collagen-lined shear layers. The right and left ventricle form separately in early stages of cardiogenesis, resulting in a dual inter-ventricular septum. In this work we compare the myocyte and sheetlet microstructure in the septum and LV free-wall in healthy and HCM hearts with in vivo diffusion tensor imaging. Results show that the right-side of the interventricular-septum has myocyte orientations not seen in the free-wall, and also lower sheetlet angles, which may indicate an RV identity in this region.
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