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Abstract #2764

Dual identity of the interventricular septum with in vivo diffusion tensor imaging

Pedro Ferreira1, Sonia Nielles-Vallespin2, Andrew Scott1, Zohya Khalique1, Dudley Pennell1, and David Firmin1

1Cardiovascular BRU, Royal Brompton Hospital, London, United Kingdom, 2NHLBI, National Institutes of Health, MD, United States

Heart muscle has a complex cellular helical arrangement, where bundles of myocytes, known as sheetlets interleave with collagen-lined shear layers. The right and left ventricle form separately in early stages of cardiogenesis, resulting in a dual inter-ventricular septum. In this work we compare the myocyte and sheetlet microstructure in the septum and LV free-wall in healthy and HCM hearts with in vivo diffusion tensor imaging. Results show that the right-side of the interventricular-septum has myocyte orientations not seen in the free-wall, and also lower sheetlet angles, which may indicate an RV identity in this region.

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