Abstract #2778

3D visualization of Vascular Cell Adhesion Molecule-1 (VCAM-1) specific Ultrasmall Superparamagnetic Iron Oxide (USPIO) nanoparticles in the atherosclerotic mouse with accelerated self-navigated radial 4D-MRI.

Kristina Andelovic¹, Patrick Winter², Thomas Kampf^2,3, Volker Herold², Peter Michael Jakob^2,4, and Wolfgang Bauer¹

¹Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Germany, ²Experimentelle Physik V, Universität Würzburg, Würzburg, Germany, ³Institut für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum Würzburg, Würzburg, Germany, ⁴Fraunhofer IIS, Fraunhofer EZRT, Magnetresonanz- und Röntgenbildgebung (MRB), Würzburg, Germany

USPIO-based, functionalized contrast agents targeting VCAM-1 enable the visualization of inflamed areas in the vessel wall during early atherogenesis. We present a novel 3D technique for coverage of the whole aortic arch at high spatial resolution and a time-resolved detection of nanoparticles with an ECG-free flow-compensated radial 3D-Cine acquisition. T2* weighted 3D-Cines were acquired using two different gradient echoes to provide phase difference maps. The results indicate a reliable detection of the nanoparticles with the new method due to a true 3D coverage of the aorta and the additional phase information.

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