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Abstract #2778

3D visualization of Vascular Cell Adhesion Molecule-1 (VCAM-1) specific Ultrasmall Superparamagnetic Iron Oxide (USPIO) nanoparticles in the atherosclerotic mouse with accelerated self-navigated radial 4D-MRI.

Kristina Andelovic1, Patrick Winter2, Thomas Kampf2,3, Volker Herold2, Peter Michael Jakob2,4, and Wolfgang Bauer1

1Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Germany, 2Experimentelle Physik V, Universität Würzburg, Würzburg, Germany, 3Institut für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum Würzburg, Würzburg, Germany, 4Fraunhofer IIS, Fraunhofer EZRT, Magnetresonanz- und Röntgenbildgebung (MRB), Würzburg, Germany

USPIO-based, functionalized contrast agents targeting VCAM-1 enable the visualization of inflamed areas in the vessel wall during early atherogenesis. We present a novel 3D technique for coverage of the whole aortic arch at high spatial resolution and a time-resolved detection of nanoparticles with an ECG-free flow-compensated radial 3D-Cine acquisition. T2* weighted 3D-Cines were acquired using two different gradient echoes to provide phase difference maps. The results indicate a reliable detection of the nanoparticles with the new method due to a true 3D coverage of the aorta and the additional phase information.

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