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Abstract #2782

Assessment of Local Pulse-Wave-Velocity Distribution in Mice using k-t BLAST MRI with Semi-Automatic Area Segmentation

Volker Herold1, Patrick Winter1, Stefan Herz2, Fabian Gutjahr1, Kristina Andelovic3, Wolfgang Rudolf Bauer3, and Peter Michael Jakob1

1Department of Physics, University of Würzburg, Würzburg, Germany, 2Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 3Department of Internal Medicine I, Division of Cardiology, University Hospital Würzburg, Würzburg, Germany

Arterial stiffness (AS) assessed by pulse wave velocity (PWV) has been shown to represent a valuable biomarker of cardiovascular disease risk. Local elastic properties of the murine aortic vessels such as the pulse-wave-velocity (PWV) can be examined using PC-MRI [1]. In the present study we provide an accelerated method based on a k-t BLAST undersampling scheme combined with a new semi-automatic segmentation algorithm to quantify the distribution of the local PWV along the aortic vessel.

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