Dixon imaging has recently been shown to be useful in contrast-enhanced MR angiography due to motion robustness and improved signal-to-noise ratio. Single-echo Dixon mostly avoids the time penalty associated with multi-echo Dixon imaging, but may incur some time penalty when choosing an echo time to give optimal signal-to-noise ratio (SNR). For dynamic scans, it is beneficial to optimize the imaging parameters for speed, even at the expense of SNR. Additionally, signal contrast can be optimized to further suppress the background water signal. The purpose of this work is to describe optimization of SNR and signal contrast for single-echo Dixon imaging.