Clinical assessment of total blood volume is significant for management of patients with decompensated chronic heart failure. We investigate the feasibility of measuring circulating blood volume as part of an interventional cardiovascular MR exam by measuring T1 changes due to the presence of Ferumoxytol - an intravascular, FDA-approved, iron supplement. Three pigs were scanned prior and twenty minutes post Ferumoxytol administration, from which a mean blood volume of 81.6 ± 1.1 mL/kg was estimated, which approximately overestimates by 15-30% from the literature. This technique has promise as a non-ionizing and non-toxic alternative to measuring patient volume.
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