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Abstract #2819

Estimation of Circulating Blood Volume using Ferumoxytol

Rajiv Ramasawmy1, Miguel Alcantar1, Jaffar M Khan1, Adrienne E Campbell-Washburn1, Anthony Z Faranesh1, and Robert J Lederman1

1National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States

Clinical assessment of total blood volume is significant for management of patients with decompensated chronic heart failure. We investigate the feasibility of measuring circulating blood volume as part of an interventional cardiovascular MR exam by measuring T1 changes due to the presence of Ferumoxytol - an intravascular, FDA-approved, iron supplement. Three pigs were scanned prior and twenty minutes post Ferumoxytol administration, from which a mean blood volume of 81.6 ± 1.1 mL/kg was estimated, which approximately overestimates by 15-30% from the literature. This technique has promise as a non-ionizing and non-toxic alternative to measuring patient volume.

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