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Abstract #2828

Evaluate Systolic and Diastolic Wall Shear Stress of Aorta for Marfan Syndrome by 4D Flow MRI

Pin-Chen Chen1, Hsin-Hui Chiu2, Wen-Yih Isaac Tseng3, and Hsu-Hsia Peng4

1Institute of Systems Neuroscience, Hsinchu, Taiwan, 2Department of Pediatrics, Taipei, Taiwan, 3Institute of Medical Device and Imaging, Taipei, Taiwan, 4Department of Biomedical Engineering and Environmental Sciences, Hsinchu, Taiwan

We aim to reveal the abnormality of plane-wise and segmental WSS in different cardiac phases of patients with Marfan syndrome (MFS) with dilated aorta. MFS group presented lower plane-wise axial WSS than normal group at ascending aorta and descending aorta during systole. In respect of segmental WSS, either in the whole cardiac cycle or during systole, MFS patients demonstrated reduced values at almost all segments in proximal ascending aorta. In conclusion, the quantitative indices of plane-wise and regional WSS clearly differentiate MFS patients from normal controls. Therefore, quantification of WSS can provide promising approaches for patient managements in the future.

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