Meeting Banner
Abstract #2833

4D Flow MRI and lumped parameter modelling for subject-specific assessment of cardiovascular function

Belen Casas1,2, Jonas Lantz1,2, Federica Viola1, Ann F. Bolger1,3, Carl-Johan Carlhäll1,2,4, Matts Karlsson2,5, and Tino Ebbers1,2

1Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Medicine, University of California San Francisco, San Francisco, CA, United States, 4Department of Clinical Physiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 5Division of Applied Thermodynamics and Fluid Mechanics, Department of Management and Engineering, Linköping University, Linköping, Sweden

Lumped-parameter models of the cardiovascular system can improve the understanding of cardiovascular function and assist treatment planning. The clinical applicability of these models improves when they are subject-specific. This work proposes an approach to personalizing a model of the heart and the systemic circulation using exclusively non-invasive measurements from routine cardiovascular MRI and 4D Flow MRI. Personalized models were constructed for eight healthy volunteers. The model-based pressures and flows agreed well with the in-vivo measurements for each subject. The proposed approach can be used to synthesize medical data into clinically relevant information and estimate parameters that cannot be measured clinically.

This abstract and the presentation materials are available to members only; a login is required.

Join Here