Abstract #2833

4D Flow MRI and lumped parameter modelling for subject-specific assessment of cardiovascular function

Belen Casas^1,2, Jonas Lantz^1,2, Federica Viola¹, Ann F. Bolger^1,3, Carl-Johan Carlhäll^1,2,4, Matts Karlsson^2,5, and Tino Ebbers^1,2

¹Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ³Department of Medicine, University of California San Francisco, San Francisco, CA, United States, ⁴Department of Clinical Physiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ⁵Division of Applied Thermodynamics and Fluid Mechanics, Department of Management and Engineering, Linköping University, Linköping, Sweden

Lumped-parameter models of the cardiovascular system can improve the understanding of cardiovascular function and assist treatment planning. The clinical applicability of these models improves when they are subject-specific. This work proposes an approach to personalizing a model of the heart and the systemic circulation using exclusively non-invasive measurements from routine cardiovascular MRI and 4D Flow MRI. Personalized models were constructed for eight healthy volunteers. The model-based pressures and flows agreed well with the in-vivo measurements for each subject. The proposed approach can be used to synthesize medical data into clinically relevant information and estimate parameters that cannot be measured clinically.

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