This study provides a comparison of four commonly-used estimates of PWV to evaluate aortic stiffness, and compares these estimates of PWV with factors indicating cardiometabolic risk in obese youth. Hemodynamic parameters and phase-contrast CMR of the aortic arch at 3.0T were measured in 19 participants (12 obese, 7 normal-weight). Four methods of estimating PWV were used (cross-correlation, foot-to-foot, half-peak, area under the curve). There was an association between increasing measures of inflammation (C-reactive protein) and BMI, indicating that aortic PWV may be associated with changes in arterial stiffness in adolescents with subclinical biomarkers of cardiovascular disease. Careful consideration should be given to the method of PWV estimation due to measurement bias.