Abstract #2843

Comprehensive Hemodynamics of Living Donor Liver Transplantion Using MRI-based In-Vitro Experiments and Computational Simulation

David Rutkowski^1,2, Scott B. Reeder^2,3,4,5,6, and Alejandro Roldán-Alzate^1,2,4

¹Mechanical Engineering, UW Madison, Madison, WI, United States, ²Radiology, UW Madison, Madison, WI, United States, ³Medical Physics, UW Madison, Madison, WI, United States, ⁴Biomedical Engineering, UW Madison, Madison, WI, United States, ⁵Medicine, UW Madison, Madison, WI, United States, ⁶Emergency Medicine, UW Madison, Madison, WI, United States

The purpose of this study was to develop a patient specific experimental methodology to complement computational surgical planning models for living donor liver transplant. 4D flow MRI was performed on one healthy liver donor before and after partial hepatectomy. Physical models of the donor vasculature were created, and experiments were conducted to measure flow and pressure throughout the system. Experimental results were compared with 4D flow measurements and simulation results. Flow measurements were significantly similar between imaging and simulation, and between simulation and experiment. This methodology will be used to improve boundary value assumptions in surgical planning models.

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