Abstract #2868

Left Atrial Enlargement and Systolic Failure Measured by Cardiac MRI in Severe Isolated Mitral Regurgitation with Preserved Left Ventricular Ejection Fraction

Xiaoxia Zhang^1,2, Steven Lloyd^3,4, Himanshu Gupta^3,4, Nouha Salibi^1,5, James Davies³, Louis Dell'Italia^3,4, and Thomas Denney^1,2

¹Auburn University MRI Research Center, Auburn University, Auburn, AL, United States, ²Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ³Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States, ⁴Birmingham Veterans Affairs Medical Center, Birmingham, AL, United States, ⁵MR R&D, Siemens Healthcare, Malvern, PA, United States

Mitral regurgitation (MR) from degeneration of the mitral valve (MV) results in a relatively low-pressure form of volume overload caused by excess volume being ejected through a secondary ejection pathway into the left atrium (LA). Optimal timing for MV repair is under debate because a spuriously normal left ventricular (LV) ejection fraction belies severe myocardial damage and that the onset of symptom has increased risk for LV dysfunction post MV repair. LA function measured by cMRI may be an important indicator for timing of MV repair before the onset of symptoms in patients with well-preserved LV systolic function.

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