Abstract #2886

Quantification of Left Ventricular Dyssynchrony and Action Time in Patients with Fabry Disease by Magnetic Resonance Tissue Phase Mapping

Bo-Yan Chuang¹, Ming-Ting Wu², Marius Menza³, Mao-Yuan Su⁴, and Hsu-Hsia Peng¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ³Medical Physics, University Hospital Freiburg, Freiburg, Germany, ⁴Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

Recent studies showed that LV dyssynchrony and deceleration time can be recognized as an important predictor of poor outcome in patients. However, the regional myocardial function investigated by MRI is less discussed. In this study, we applied MR tissue phase mapping (TPM) and aim to investigate the myocardial dyssynchrony and action time in LV for Fabry disease (FD). We observed increased longitudinal dyssynchrony and lower systolic action time in FD group. In conclusion, the quantification of LV myocardial dyssynchrony and action time may provide useful information to comprehend the impaired cardiac manifestation and diastolic dysfunction in patients with FD.

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