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Abstract #2898

Probing infiltration of the normal brain by glioblastoma using magnetic resonance perfusion and permeability techniques

Antoine Vallatos1, Joanna Birch2, Lindsay Gallagher1, Haitham F. I. Al-Mubarak1, Lesley Gilmour2, Anthony J. Chalmers2, and William M. Holmes1

1Glasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom, 2Translational Radiation Biology, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

MRI techniques probing brain perfusion and blood-brain barrier (BBB) permeability were assessed in their ability to detect low tumour invasion in mouse glioblastoma models. A multiple boli Arterial Spin Labeling technique was optimised, achieving high SNR perfusion imaging. Diffusion-weighted arterial spin labelling allowed to separate fast motion vascular components of the signal from slow motion tissue components, providing with BBB permeability weighted maps. Evaluation was performed by comparison with conventional MRI and immunohistochemistry sections (HLA) cut in the MRI plane . Both perfusion weighted maps and BBB permeability weighted maps allowed to identify low tumour regions not detected with conventional MRI techniques.

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