Meeting Banner
Abstract #2961

Optimizing the precision and accuracy of sampling schemes for T2* quantification of the fast biexponential decay of sodium MRI

Jonathan M. Lommen1, Sebastian Flassbeck1, Nicolas G.R. Behl1, Mark E. Ladd1, and Armin M. Nagel1,2

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Sodium imaging is mainly performed with spin-density weighted sequences to quantify tissue sodium concentration. However, relaxation weighting can add additional specific information. We pursue appropriate sampling for low SNR and fast biexponential decay. The accuracy and precision of typical T2* measurements is determined for different sampling schemes by simulation and phantom measurements. We developed a dedicated sampling scheme for brain parenchyma employing numerical optimization. The results suggest that averaging is preferable to increase reliability compared to denser temporal sampling. In-vivo comparison confirmed the advantage of the optimized patter with increased separation of the decay components.

This abstract and the presentation materials are available to members only; a login is required.

Join Here