Abstract #2964

Sodium MRI of the thyroid gland at 7 tesla

Dimitri Welting¹, Wybe van der Kemp¹, Ingmar Voogt¹, Armin Nagel^2,3, Mark Ladd², Peter Luijten¹, Alexander Raaijmakers^1,4, Dennis Klomp¹, Nicolas Behl², and Mariska Luttje¹

¹Imaging Division, University Medical Center, Utrecht, Netherlands, ²Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ⁴Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, Netherlands

This work shows the potential of sodium imaging of the thyroid gland in vivo at 4mm isotropic resolution integrated to ¹H imaging. An optimized setup combined with tuned sequences and B₁ corrections enables quantitative sodium mapping of the thyroid gland and its surrounding tissue. The thyroid gland has the highest concentration of sodium in this part of the neck, estimated to be 64.5 mmol/L in vivo. Sodium imaging might open up the detection of (lymph node) metastases of thyroid cancer, as they are expected to exceed the healthy concentration of sodium detected in the head and neck region.

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