Abstract #2967

7T MRSI Identifies Neuronal and Axonal Injury in a Limbic Network in MRI Negative Veterans with mTBI and PTSD

Hoby Hetherington¹, Anne VanCott², Victor Yushmanov¹, Jodilyn Roberts³, Daniela Mejia², Monique Kelley⁴, and Jullie Pan²

¹Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ²Neurology, University of Pittsburgh, Pittsburgh, PA, United States, ³Neurology, Pittsburgh Veterans Administration Medical Center, PA, United States, ⁴Biostatistics, Pittsburgh Veterans Administration Medical Center, PA, United States

Following mild traumatic brain injury (mTBI) many veterans continue to experience persistent symptoms despite an absence of significant findings on conventional MRI. In this study we acquired MRSI and volumetric data from veterans with a history of mTBI and PTSD, healthy age matched controls and veterans with PTSD without a history of mTBI. Data was acquired from the hippocampus (single slice MRSI) and cingulate (multiband MRSI). Significant declines in NAA/Ch were seen in the hippocampal formation in comparison to healthy controls and veterans with PTSD. Further, reductions in hippocampal NAA/Ch were statistically correlated with reductions in NAA/Ch from the cingulate

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