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Abstract #3004

The effect of sex on neurochemical profile quantified from the human brain at 7T

Petr Bednarik1, Ivan Tkac1, Lynn Eberly2, and Silvia Mangia1

1Department of Radiology, CMRR, University of Minnesota, Minneapolis, MN, United States, 2School of Public Health, University of Minnesota, Minneapolis, MN, United States

Sex is a critical biological factor that needs to be factored into study designs and analyses. In the present work, we sought to quantify sex-related differences of neurochemical profiles, utilizing 1H MRS data from the visual cortex of 22 healthy females (age 24±6 years) and 27 males (age 26±6 years) acquired at 7 T. Whereas there was a trend of sex-related differences for few metabolites, no statistically significant differences were observed above the attained metabolite sensitivity threshold of 0.2 µmol/g. The results indicate that sex is not a major confounding variable for MRS experiments performed on the visual cortex of young subjects.

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