Despite advancements in single-voxel hippocampal 1H MR spectroscopy, low abundant and J-coupled metabolites, which are critically involved in neuro-energetics, memory and excitation/inhibition balance, are still poorly quantified at 3T. Hippocampal 1H MRS at 7T may benefit from higher SNR and better spectral dispersion. Thus, the precision and test-retest reproducibility of quantification achieved at 7T using semi-LASER sequence was compared to the outcome of a similarly designed 3T study. The higher SNR at 7T relative to 3T allowed using smaller voxel for more precise selection of hippocampal gray matter while demonstrating improved quantification of J-coupled and/or low abundant metabolites.
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