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Abstract #3021

In-vivo testing of automatic voxel prescription for high inter-subject reproducibility in single-voxel MR spectroscopy

Young Woo Park1, Dinesh K Deelchand2, James M. Joers2, Brian J. Soher3, Peter B. Barker4, HyunWook Park1, Gülin Öz2, and Christophe Lenglet2

1Electrical Enginnering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN, United States, 3Department of Radiology, Duke University Medical Center, Durham, NC, United States, 4Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

In this study, we present the implementation and outcome of a scheme for automatic voxel placement in single-voxel spectroscopy. The scheme is based on transfer of voxels prescribed on an atlas to the subject images during the scanning session and allows fast and reliable placement of voxels for spectroscopy measurements. 1H spectra of three different volumes of interest (VOIs) from multiple subjects were measured with a Siemens 3T scanner following automated and manual VOI placements. MRS data acquired using automatic placement produced spectral quality comparable to manual placement, while yielding better cross-subject spatial consistency than manual placement.

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