In this study, we present the implementation and outcome of a scheme for automatic voxel placement in single-voxel spectroscopy. The scheme is based on transfer of voxels prescribed on an atlas to the subject images during the scanning session and allows fast and reliable placement of voxels for spectroscopy measurements. 1H spectra of three different volumes of interest (VOIs) from multiple subjects were measured with a Siemens 3T scanner following automated and manual VOI placements. MRS data acquired using automatic placement produced spectral quality comparable to manual placement, while yielding better cross-subject spatial consistency than manual placement.
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