Abstract #3031

Hyperpolarization of [4-13C]5-aminolevulinic acid

Stephen J. DeVience¹, Graeme Woodworth², Joseph P. Y. Kao^3,4, and Dirk Mayer¹

¹Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States, ³Center for Biomedical Engineering and Technology (BioMET), University of Maryland School of Medicine, Baltimore, MD, United States, ⁴Physiology, University of Maryland School of Medicine, Baltimore, MD, United States

We performed the first DNP hyperpolarization of ¹³C-labeled 5-aminolevulinic acid (5-ALA), achieving 13% polarization at dissolution and measuring a T₁ of 20 s. 5-ALA is used for fluorescent imaging and photodynamic therapy of glioblastoma, and our results suggest it is also a promising substrate for hyperpolarized metabolic imaging of this cancer.

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