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Abstract #3036

photo-CIDNP for 19F MR amino acid-protein interaction studies in physiological solvents

Frederike Euchner1, Markus Plaumann1, Thomas Trantzschel1, Joachim Bargon2, Ute Bommerich1, and Johannes Bernarding1

1Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, 2Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

Fluorinated amino acids are of high interest in biochemistry and pharmaceutics. The low 19F MR signal was increased employing hyperpolarization (photo-Chemical Induced Dynamic Nuclear Polarization, photo-CIDNP). 3-Fluoro-tyrosine in physiologic salt solution was hyperpolarized in presence of an albumin derivative using a low cost LED allowing repetitive irradiation and increasing the hyperpolarized signal. A clear 19F signal enhancement could be observed. In comparison to past examinations with a laser system, only small temperature changes caused by LED light irradiation were measured in the current study.

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