Abstract #3036

photo-CIDNP for 19F MR amino acid-protein interaction studies in physiological solvents

Frederike Euchner¹, Markus Plaumann¹, Thomas Trantzschel¹, Joachim Bargon², Ute Bommerich¹, and Johannes Bernarding¹

¹Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, ²Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

Fluorinated amino acids are of high interest in biochemistry and pharmaceutics. The low ¹⁹F MR signal was increased employing hyperpolarization (photo-Chemical Induced Dynamic Nuclear Polarization, photo-CIDNP). 3-Fluoro-tyrosine in physiologic salt solution was hyperpolarized in presence of an albumin derivative using a low cost LED allowing repetitive irradiation and increasing the hyperpolarized signal. A clear ¹⁹F signal enhancement could be observed. In comparison to past examinations with a laser system, only small temperature changes caused by LED light irradiation were measured in the current study.

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