Abstract #3045

Practical Considerations of Quantitative kPL Estimation in Hyperpolarized-13C Imaging in Response to Pulse Sequence Design and Parameters

Hsin-Yu Chen^1,2, Jeremy W. Gordon¹, Robert A. Bok¹, Peng Cao¹, Cornelius von Morze¹, Eugene Milshteyn^1,2, Ralph E. Hurd³, John Kurhanewicz^1,2, Peder E.Z. Larson^1,2, and Daniel B. Vigneron^1,2

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²UCSF/UC Berkeley Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, ³GE healthcare, Menlo Park, CA, United States

Hyperpolarized-¹³C MRI has recently enabled imaging of cancer pathophysiology with high spatiotemporal resolution in humans. Quantitative measure of tumor metabolism can be made possible by estimating conversion rate constants (e.g. k_PL for pyruvate-to-lactate). We have identified 3 systematic sources affecting k_PL estimation that were introduced by MR acquisition and pulse sequences – an RF-spoiling effect, a T₂*-weighting factor, and a crusher flow-suppression phenomenon. These sources were investigated using a transgenic cancer model and simulations.

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