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Abstract #3047

Whole-Brain Visualization of Manganese Deposition in Welders

Chien-Lin Yeh1,2, Courtney Beth Johnson3, Ruoyun Ma1,2, Shalmali Dharmadhikari4, Sandy Snyder1, and Ulrike Dydak1,2

1Purdue University, West lafayette, IN, United States, 2Indiana University School of Medicine, Indianapolis, IN, United States, 3Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States, 4Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States

While the paramagnetic properties of Mangnaese (Mn) make it useful as a contrast agent for MRI, little is known about the spatial distribution of Mn deposition in the human brain due to occupational Mn exposure. Using a novel approach to analyze and visualize whole brain Mn deposition in welders, Mn was elevated in motor and cognitive associated networks, consistent with respective reports on impaired neuropsychological function. Our Mn maps even reveal the diffusion of Mn along white matter tracts for the first time in humans. These findings help explain how Mn exposure affects the function of particular brain networks.

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