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Abstract #3056

Facile and Novel Synthesis of MR/NIR Dual Modal Contrast Agent for In Vivo Non-invasive Molecular Imaging

Hye Sun Park1, Mi Young Cho1, Hyunseung Lee1, and Kwan Soo Hong1

1Bioimaging Research Team, Korea Basic Science Institute, Cheongju-si, Korea, Republic of

We proposed the phase transferring method of hydrophobic magnetic nanoparticles without any chemical modifications, for use as a magnetic resonance (MR)/near-infrared (NIR) fluorescence bimodal imaging contrast agent. Indocyanine green (ICG) was used both as an optical component and a surfactant for phase transfer with no superfluous moiety. ICG-MNP-labeled dendritic cells presented MR/NIR dual-modal imaging properties with high and sensitive detection ability for a long time. We expect that this novel MR/NIR contrast agent with sensitive detection and simultaneous imaging capability can be used in the imaging and tracking of immune cells to confirm immunotherapeutic efficacy.

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