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Abstract #3062

One-pot microwave synthesis of fluorinated silicon nanoparticles for dual 19F-MRI and fluorescence imaging

Sha Li1, Shizhen Chen1, Yaping Yuan1, Lili Ren1, Yuqing Yang1, and Xin Zhou1

1Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People's Republic of China

In this study, we have designed a one-pot microwave strategy for facile and rapid synthesis of blue-emitting 19F-SiNPs. The as prepared 19F-SiNPs significantly exhibited ultral small sizes, excellent water solubility and strong fluorescence. Besides, The chemically and magnetically equivalent trifluoromethyl groups grafted on the prepared nanoparticles displayed a single NMR signal, which offered advantages to maximize the generated magnetic resonance signal. In summary, such resultant 19F-SiNPs are particularly suitable for real-time 19F-MRI and fluorescence dual modality imaging.

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