Abstract #3062

One-pot microwave synthesis of fluorinated silicon nanoparticles for dual 19F-MRI and fluorescence imaging

Sha Li¹, Shizhen Chen¹, Yaping Yuan¹, Lili Ren¹, Yuqing Yang¹, and Xin Zhou¹

¹Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People's Republic of China

In this study, we have designed a one-pot microwave strategy for facile and rapid synthesis of blue-emitting ¹⁹F-SiNPs. The as prepared ¹⁹F-SiNPs significantly exhibited ultral small sizes, excellent water solubility and strong fluorescence. Besides, The chemically and magnetically equivalent trifluoromethyl groups grafted on the prepared nanoparticles displayed a single NMR signal, which offered advantages to maximize the generated magnetic resonance signal. In summary, such resultant ¹⁹F-SiNPs are particularly suitable for real-time ¹⁹F-MRI and fluorescence dual modality imaging.

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