Long term hemodialysis treatment for end stage renal disease (ESRD) is associated with a time dependent increase in cardiac death. The inability to use late gadolinium enhancement (LGE) cardiac MRI (CMR) in patients with renal dysfunction impedes the noninvasive monitoring of fibrosis progression and appropriate treatment selection in the population. We used magnetization transfer (MT) weighted CMR to monitor the progression of ventricular fibrosis over 1 year in patients with ESRD. While no major changes in hypertrophy or contractility were apparent, pervasive increases in myocardial signal was measured by MT-weighted CMR, consistent with reduced MT and progressive fibrosis development.
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