Diffusion tensor (DT) cardiovascular magnetic resonance (CMR) can provide myocardial microstructural information using either motion compensated spin echo (SE) or stimulated echo acquisition mode (STEAM) sequences. Here we present the first DT-CMR data from a cohort of hypertrophic cardiomyopathy patients using SE, and compare parameters obtained from SE and STEAM sequences at 3T in two phases of the cardiac cycle. We demonstrate that whilst reliability measures, diffusivity, and anisotropy differ between the sequences, both approaches are able to detect the sheetlet microstructure that is integral to wall thickening during cardiac contraction and shown to be aberrant in this condition.
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