Abstract #3143

Accelerated Cardiac Cine “Watermark” MRI provides Cardiac Function via Magnitude Cine and 2D Myocardial Strain via Spatially Modulated Phase

Ronald J Beyers¹, Davis M Vigneault^2,3,4, Nouha Salibi^1,5, David A Bluemke⁴, and Thomas S Denney¹

¹MRI Research Center, Auburn University, Auburn, AL, United States, ²Department of Engineering Science, University of Oxford, Oxford, United Kingdom, ³Sackler School of Graduate Biomedical Sciences, School of Medicine, Boston, MA, United States, ⁴Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ⁵MR R&D, Siemens Healthcare, Malvern, PA

We developed a parallel imaging accelerated Cine Watermark (CWM) sequence to provide normal cine magnitude images plus phase image-only multi-directional spatial encoding for quantitative cine strain -- while requiring no extra operator effort. Spatial cosine modulation post-processed by complex image sum/differencing produced separate normal magnitude cine and unique phase-only spatial modulation for strain calculation. In vivo human scans demonstrated good magnitude cine and phase-only quantified displacement. Cardiac strains were tracked by a novel non-linear least squares method combining quadratic b-spline contours, nearest neighbor optimized phase tracking, and physically-motivated regularizers. Cardiac left ventricular, short-axis, circumferential strain results agreed with previous literature.

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