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Abstract #3145

Cardiac function relation to preload variation based on free breathing motion

Teodora Chitiboi1, Rebecca Ramb1, Eve Piekarski2, Li Feng1, Anja Hennemuth3, and Leon Axel1

1Radiology, New York University School of Medicine, New York, NY, United States, 2Nuclear Medicine Ward, Pitié Salpétrière Hospital, Paris, Paris, France, 3Fraunhofer MEVIS, Germany

Free-breathing cardiac cine MRI provides novel information on cardiac dynamics. In this work, we investigate the relation between cardiac function and left-ventricular preload variations induced by respiratory motion, in normal subjects and patients. We used the left-ventricular diameter perpendicular to the septum as a measure of preload and the relative change in diameter between end-systole and end-diastole as a measure of functional response. There was a significantly larger change in diameter during the respiratory cycle for normal subjects compared to patients. We also found a significant correlation between preload and cardiac function for normal subjects, which was reduced for patients.

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