Abstract #3145

Cardiac function relation to preload variation based on free breathing motion

Teodora Chitiboi¹, Rebecca Ramb¹, Eve Piekarski², Li Feng¹, Anja Hennemuth³, and Leon Axel¹

¹Radiology, New York University School of Medicine, New York, NY, United States, ²Nuclear Medicine Ward, Pitié Salpétrière Hospital, Paris, Paris, France, ³Fraunhofer MEVIS, Germany

Free-breathing cardiac cine MRI provides novel information on cardiac dynamics. In this work, we investigate the relation between cardiac function and left-ventricular preload variations induced by respiratory motion, in normal subjects and patients. We used the left-ventricular diameter perpendicular to the septum as a measure of preload and the relative change in diameter between end-systole and end-diastole as a measure of functional response. There was a significantly larger change in diameter during the respiratory cycle for normal subjects compared to patients. We also found a significant correlation between preload and cardiac function for normal subjects, which was reduced for patients.

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