This study evaluated the individual T1rho and combined performances of T1rho, IVIM and DKI in predicting HBV related liver fibrosis. Twenty-two patients with HBV related liver fibrosis and twenty healthy control subjects were underwent whole-liver T1rho MR imaging, IVIM and DKI. The T1rho, D, D*, f , MD and MK values were compared between the two groups, and then the single and combined diagnostic efficiency of T1rho, IVIM and DKI was analyzed. Our results showed liver T1rho and MK increased and D, f, MD decreased in normal control group, and liver T1rho and MD had significantly difference between the two groups. T1rho had a moderate diagnostic efficiency, IVIM and DKI had a mild diagnostic efficiency to detect fibrosis. While, the combination of T1rho, IVIM and DKI improved the diagnostic efficiency significantly and had a good diagnostic efficiency to detect fibrosis. We conclude T1rho can be used to predicting liver fibrosis effectively, and IVIM and DKI can effectively complement existing T1rho MR imaging in predicting of liver fibrosis.
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