Abstract #3166

Focus or Spread? An Investigation of the Effects of b-Value Acquisition Strategies on the Stability and Bias of Prostate Diffusion Imaging Results

Xiaodong Zhong^1,2, Phil Young³, Peter Kollasch⁴, Venkata Chebrolu⁴, and Brian M. Dale⁵

¹MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States, ²Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ³Department of Radiology, Mayo Clinic, Rochester, MN, United States, ⁴MR R&D Collaborations, Siemens Healthcare, Rochester, MN, United States, ⁵MR R&D Collaborations, Siemens Healthcare, Cary, NC, United States

In order to investigate the effects of b-value acquisition strategies on the stability and bias of the prostate DWI results, including calculated b-value images and ADC, a framework was developed. Using the DWI data from 8 prostate patients, this study revealed that acquiring many averages at a few b-values increases bias compared to acquiring few averages at many b-values, particularly when large numbers of averages have been removed. The framework and strategies proposed in this work may provide a useful tool to design b-value acquisition protocols to achieve the stability of prostate DWI results in clinic.

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