Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) is a novel functional MRI technique which has been demonstrated with excellent diagnostic capability. Respiratory motion artifacts are the main source of error in the acquisition and quantification of parameters for multi-b-value DWI. This work develops a reliable approach to compensate for misalignments between multi-b-value images during free-breathing based on pyramidal Lucas-Kanade registration. Preliminary results show that our proposed approach can well correct motion-related artifacts misalignment. In addition, visual quality of the ADC, f, D and D* maps indicate that contours of kidney look better defined after registration.
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