Meeting Banner
Abstract #3177

Prognostic value of the pretreatment apparent diffusion coefficient (ADC) for outcome prediction of chemorefractory colorectal liver metastases undergoing 90-Yttrium Radioembolization

Frederic Carsten Schmeel1, Julian Alexander Luetkens1, Frank Träber1, Leonard Christopher Schmeel1, Amir Sabet2, Birgit Simon1, Hans Heinz Schild1, and Dariusch Reza Hadizadeh1

1Department of Radiology, University Hospital Bonn, Bonn, Germany, 2Department of Nuclear Medicine, University Hopsital Saarland, Homburg/Saar, Germany

Imaging-based prediction of therapeutic response is highly desireable for further therapy decisions in patients with advanced malignancies. Therefore, we investigated whether pre-treatment values of the apparent diffusion coefficient (ADC) on diffusion-weighted MRI could predict the outcome of patients with liver-predominant metastatic colorectal cancer prior to 90-Yttrium microspheres radioembolization. Uni- and multivariate analyses were performed comparing various variables with potential impact on progression-free and overall survival. Our results reveal that pathologic pre-treatment ADC, alongside with established clinical parameters, is a strong and independent predicor of both progression-free and overall survival before RE treatment.

This abstract and the presentation materials are available to members only; a login is required.

Join Here