Imaging-based prediction of therapeutic response is highly desireable for further therapy decisions in patients with advanced malignancies. Therefore, we investigated whether pre-treatment values of the apparent diffusion coefficient (ADC) on diffusion-weighted MRI could predict the outcome of patients with liver-predominant metastatic colorectal cancer prior to 90-Yttrium microspheres radioembolization. Uni- and multivariate analyses were performed comparing various variables with potential impact on progression-free and overall survival. Our results reveal that pathologic pre-treatment ADC, alongside with established clinical parameters, is a strong and independent predicor of both progression-free and overall survival before RE treatment.
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