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Abstract #3187

Diffusion and perfusion parameters extracted by bi-exponential model are markers of healthy human placenta development.

Michele Guerreri1,2, Silvia Capuani2, Amanda Antonelli3, and Lucia Manganaro3

1SAIMLAL Dept., Morphogenesis & Tissue Engineering, Sapienza University of Rome, Rome, Italy, 2Physics Dept., CNR ISC UOS Roma Sapienza, Rome, Italy, 3Radiology Dept., Department of Radiology, Sapienza University of Rome, Rome, Italy

The purpose was to investigate the potential of bi-exponential model of diffusion-weighted (DW) signal decay to quantify diffusion and perfusion in healthy human placentas. The relation between diffusion and perfusion parameters with microstructural changes occurring during placenta development was also investigated. 26 pregnant women underwent DW examination. Apparent diffusion coefficient D, pseudo-perfusion fraction f and pseudo-diffusion coefficient D* were obtained in specific placental regions. The Pearson correlations between D, D*,f and clinical data (Gestational Age, Body-Mass Index and basal Glycaemia) were evaluated. D and f show to be good indicators of placenta morphological changes due to Gestational Age.

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