Abstract #3189

Radiologic-Pathologic Correlation and MR Analysis of Hepatocellular Adenoma Subtypes.

Daniel Kehler¹, George Yang², Christine Zwart¹, Marcela Salomao³, and Alvin Silva¹

¹Radiology, Mayo Clinic Arizona, Scottsdale, AZ, United States, ²University of Pennsylvania, PA, United States, ³Pathology, Mayo Clinic Arizona, Scottsdale, AZ, United States

Hepatocellular adenomas (HCA) present as four genetic subtypes that vary greatly in their clinical behavior and MR appearance. Inflammatory HCA has the highest propensity for hemorrhage, is characterized by hyperintense T2 signal, and displays arterial hyper-enhancement that persists on portal venous and delayed phases. HNF1-alpha mutated HCA portends a good prognosis, and is characterized by diffuse intracellular lipid. Beta-catenin HCA is less common and difficult to diagnose on imaging, though arguably the most important because of its high likelihood for malignant transformation. Unclassified HCA is not well understood in terms of imaging or clinical significance.

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