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Abstract #3209

Variable Density CAIPIRINHA for Highly Accelerated Volumetric Dynamic Contrast-Enhanced Imaging of Liver

Fuyixue Wang1,2, Zijing Dong1, Feiyu Chen3,4, Yuxin Hu3,4, Jia Ning1, Feng Huang5, and Huijun Chen1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People's Republic of China, 2Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States, 4Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 5Neusoft Medical System, People's Republic of China

Dynamic Contrast-Enhanced (DCE) imaging is widely used in detection and characterization of many liver diseases. In clinical practice, breath holding is commonly used to overcome respiratory motion and get high quality images. However, long breath holds can be painful or unavailable for some patients. To address this problem, we present a variable density 2D CAIPIRINHA sampling technique with a novel reconstruction framework for highly accelerated volumetric DCE liver imaging. Simulation and in-vivo experiments were performed to evaluate the performance of the proposed method compared with other current techniques. The results show great improvement of image quality within shorter acquisition time.

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